Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.801


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX1chr10_+_1028810500.638.3e-03Click!
TLX3chr5_+_1706688920.253.5e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_45699830 6.308 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr6_-_31853027 4.637 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr5_+_38481392 4.153 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr11_+_74539679 3.974 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chrX_-_53327473 3.382 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr11_-_71429747 3.377 NUMA1
nuclear mitotic apparatus protein 1
chr1_-_1840564 3.303 NM_178545
TMEM52
transmembrane protein 52
chr22_+_40093245 3.175 NM_001145398
TEF
thyrotrophic embryonic factor
chr9_+_135389698 3.162 NM_014694
ADAMTSL2
ADAMTS-like 2
chr3_+_46717826 3.126 NM_147196
TMIE
transmembrane inner ear
chr19_+_10258642 3.114 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr15_+_72828235 2.905 NM_000761
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr14_-_80934523 2.827 NM_033104
STON2
stonin 2
chr12_-_50871953 2.807 NM_001081492
NM_182507
KRT80

keratin 80

chrX_+_106057984 2.677 CLDN2
claudin 2
chr14_+_72773957 2.629 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chr17_+_75507750 2.622


chr9_+_137694988 2.517 NM_001001676
LCN9
lipocalin 9
chr9_-_139183675 2.412


chr12_-_51514328 2.372 NM_175834
KRT79
keratin 79
chrX_-_129347101 2.351 NM_178471
GPR119
G protein-coupled receptor 119
chr17_+_7125702 2.324 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr9_+_101623957 2.316 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr11_+_119616112 2.224 NM_014352
POU2F3
POU class 2 homeobox 3
chr11_-_3104413 2.164 OSBPL5
oxysterol binding protein-like 5
chr7_+_120752656 2.128 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr20_-_60375695 2.111 NM_005560
LAMA5
laminin, alpha 5
chr15_-_38420414 2.108 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr11_+_61714263 2.103 NM_006552
SCGB1D1
secretoglobin, family 1D, member 1
chr7_-_27153892 2.019 NM_024014
HOXA6
homeobox A6
chr5_-_172130766 1.992 NM_004417
DUSP1
dual specificity phosphatase 1
chr12_+_109956210 1.987 NM_015267
CUX2
cut-like homeobox 2
chr17_-_44226595 1.980 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr22_-_22970850 1.979 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr7_+_150376537 1.956 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr7_-_150283794 1.936 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chrX_-_128616594 1.925 NM_017413
APLN
apelin
chr7_-_5429702 1.923 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr5_+_1254709 1.871 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr7_-_99899829 1.869 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chr5_-_148738980 1.862 NM_014443
IL17B
interleukin 17B
chr19_-_1989937 1.837 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr7_-_36991189 1.816 NM_001039459
ELMO1
engulfment and cell motility 1
chr3_+_42675841 1.789 ZBTB47
zinc finger and BTB domain containing 47
chr4_+_141484046 1.773 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr8_-_22044463 1.742 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr9_-_131555111 1.733 NM_004878
PTGES
prostaglandin E synthase
chr19_+_55627971 1.702 NM_004533
MYBPC2
myosin binding protein C, fast type
chr7_+_102340579 1.692 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr12_-_8271460 1.691 NM_018088
FAM90A1
family with sequence similarity 90, member A1
chr6_+_167658563 1.684 NM_031949
TTLL2
tubulin tyrosine ligase-like family, member 2
chr1_+_226399026 1.674 NM_001159391
GUK1
guanylate kinase 1
chr1_+_1836125 1.667 NM_138705
CALML6
calmodulin-like 6
chr16_+_2071631 1.654 TSC2
tuberous sclerosis 2
chrX_+_128942435 1.639


chr9_+_130719034 1.632 LRRC8A
leucine rich repeat containing 8 family, member A
chr16_+_2138688 1.627 RAB26
RAB26, member RAS oncogene family
chr17_-_77394872 1.626 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr16_+_2138608 1.603 NM_014353
RAB26
RAB26, member RAS oncogene family
chr16_+_55612125 1.586 NLRC5
NLR family, CARD domain containing 5
chr16_+_56219802 1.585 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_-_39910296 1.575 NM_032526
NT5C1A
5'-nucleotidase, cytosolic IA
chr14_+_69021149 1.564 NM_001161498
UPF0639
UPF0639 protein
chr15_+_63156206 1.525 NM_001101362
KBTBD13
kelch repeat and BTB (POZ) domain containing 13
chr12_+_120944174 1.514 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr3_-_198784590 1.502 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr8_+_144366442 1.489 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr19_-_1763198 1.487 NM_001178002
NM_138813
ATP8B3

ATPase, aminophospholipid transporter, class I, type 8B, member 3

chr17_+_37693090 1.476 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr8_-_143864933 1.431 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr12_-_54392328 1.430 NM_001144997
ITGA7
integrin, alpha 7
chr11_+_64737886 1.415 NM_001004326
SLC22A20
solute carrier family 22, member 20
chr5_-_138746917 1.406 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr12_+_123339662 1.400 NM_181709
FAM101A
family with sequence similarity 101, member A
chr3_+_8750485 1.399 NM_033337
NM_001234
CAV3

caveolin 3

chr3_+_127743868 1.397 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr17_-_928960 1.380 ABR
active BCR-related gene
chrX_+_41191630 1.374 NM_022567
NYX
nyctalopin
chr8_-_10550026 1.371 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr19_+_3958690 1.353 NM_015897
PIAS4
protein inhibitor of activated STAT, 4
chr11_+_1200868 1.347 NM_002458
MUC5B
mucin 5B, oligomeric mucus/gel-forming
chr16_+_620932 1.345 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr19_-_53950458 1.339 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr6_-_2580296 1.337 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr9_+_123083540 1.330 GSN
gelsolin
chr16_-_2204776 1.327 NM_001042371
PGP
phosphoglycolate phosphatase
chr10_-_51156329 1.324 NM_001077685
AGAP4
AGAP7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 7
chrX_-_54539043 1.315 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr22_-_17489718 1.310 DGCR2
DiGeorge syndrome critical region gene 2
chr9_+_115396020 1.309 NM_144489
RGS3
regulator of G-protein signaling 3
chr1_-_151630168 1.305 NM_002964
S100A8
S100 calcium binding protein A8
chr16_+_69060325 1.287 FUK
fucokinase
chr19_+_40541327 1.286 NM_005304
FFAR3
free fatty acid receptor 3
chr5_-_138746840 1.282 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr20_-_61574259 1.281 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr5_-_54317102 1.280 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr19_+_15612706 1.275 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr2_+_241156776 1.274 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr19_+_10404110 1.273 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr11_+_74548472 1.264 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr8_+_144420939 1.252 NM_138465
GLI4
GLI family zinc finger 4
chr17_+_21249040 1.247 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr3_-_11585264 1.243 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr3_+_188397967 1.242 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr1_-_109201228 1.238 NM_152763
AKNAD1
AKNA domain containing 1
chrX_+_106048245 1.236 NM_001171095
CLDN2
claudin 2
chr2_+_97696462 1.235 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr1_-_171286634 1.232 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr19_+_7493436 1.221 NM_020533
MCOLN1
mucolipin 1
chr18_-_72857665 1.221 MBP
myelin basic protein
chr1_-_16217025 1.213 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr8_-_42184350 1.212 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chrX_-_110541029 1.211 NM_000555
DCX
doublecortin
chr19_+_49894260 1.203 NM_001039213
CEACAM16
carcinoembryonic antigen-related cell adhesion molecule 16
chr5_-_73973004 1.193 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr10_+_80743769 1.192 ZMIZ1
zinc finger, MIZ-type containing 1
chr9_+_138991835 1.188 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_+_33003814 1.185 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr1_+_43508251 1.180 NM_144626
TMEM125
transmembrane protein 125
chr1_-_41722883 1.177 NM_001956
EDN2
endothelin 2
chr9_-_97308687 1.176 PTCH1
patched 1
chr11_+_1200894 1.172 MUC5B
mucin 5B, oligomeric mucus/gel-forming
chr3_-_157054860 1.171 NM_001190992
NM_004733
SLC33A1

solute carrier family 33 (acetyl-CoA transporter), member 1

chr19_+_59973074 1.168 NM_014218
KIR2DS2
KIR2DL1
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
chr9_-_139184247 1.168 NM_001013653
LRRC26
leucine rich repeat containing 26
chr9_+_138991775 1.152 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr10_-_100164877 1.151 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr8_-_42184194 1.149 PLAT
plasminogen activator, tissue
chr17_-_40348378 1.147 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr9_-_137731139 1.146 NM_001012415
NM_001101677
SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

chr15_-_57452357 1.143 MYO1E
myosin IE
chr1_-_199608941 1.142 TNNT2
troponin T type 2 (cardiac)
chr8_+_22900863 1.138 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr7_+_101978777 1.137 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr1_-_171441234 1.136 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_+_16247870 1.133 NM_001165945
CLCNKB
chloride channel Kb
chr16_+_3642940 1.132 NM_005223
DNASE1
deoxyribonuclease I
chr15_-_57452361 1.127 NM_004998
MYO1E
myosin IE
chr11_+_1848674 1.116 NM_001013254
NM_001013255
LSP1

lymphocyte-specific protein 1

chrX_+_48529905 1.112 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr1_+_1207351 1.110 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chr17_-_73867748 1.110 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr16_+_84202515 1.096 NM_001134473
KIAA0182
KIAA0182
chr16_+_2807164 1.094 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr16_+_73810383 1.090 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr16_+_2807228 1.085 PRSS21
protease, serine, 21 (testisin)
chr1_+_9571518 1.079 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr1_+_33003847 1.073 KIAA1522
KIAA1522
chr7_+_142723340 1.058 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr3_+_38322430 1.057 NM_004803
SLC22A14
solute carrier family 22, member 14
chrX_-_132947141 1.051 GPC3
glypican 3
chr10_-_69267774 1.044 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr16_+_55456619 1.037 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr22_-_41672990 1.034 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr1_+_18680010 1.023 NM_152375
KLHDC7A
kelch domain containing 7A
chr16_-_85099941 1.018 LOC400550
hypothetical LOC400550
chr8_-_29262240 1.017 NM_057158
DUSP4
dual specificity phosphatase 4
chr3_+_42107711 1.007 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr15_+_64661560 1.004


chr9_+_138677197 1.000 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr1_+_1971762 0.998 NM_002744
PRKCZ
protein kinase C, zeta
chrX_+_152423277 0.990 BGN
biglycan
chr15_-_57452345 0.977 MYO1E
myosin IE
chr9_-_116196505 0.975 NM_030767
AKNA
AT-hook transcription factor
chr19_+_40849554 0.973 NM_007000
UPK1A
uroplakin 1A
chr3_-_42719322 0.972 NM_020707
HHATL
hedgehog acyltransferase-like
chr7_-_99914690 0.971 NM_030935
TSC22D4
TSC22 domain family, member 4
chr18_-_72858037 0.961 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr21_-_45786709 0.952 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr19_-_55912006 0.951 NM_016148
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr13_+_113369470 0.950 NM_002929
GRK1
G protein-coupled receptor kinase 1
chr7_-_100077072 0.950 NM_003227
TFR2
transferrin receptor 2
chr5_+_357290 0.949 NM_020731
AHRR
aryl-hydrocarbon receptor repressor
chr1_-_240679380 0.948 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr16_-_27806978 0.946 NM_144675
GSG1L
GSG1-like
chr1_+_1233834 0.945 NM_153339
PUSL1
pseudouridylate synthase-like 1
chr19_+_876984 0.945 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr1_-_16411690 0.933 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr22_+_48971067 0.931 TRABD
TraB domain containing
chr1_+_100776280 0.926 NM_022049
GPR88
G protein-coupled receptor 88
chr19_+_2173415 0.925 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chrX_+_17563333 0.924 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr17_+_71232370 0.923 NM_001005619
ITGB4
integrin, beta 4
chr12_-_10173947 0.921 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr16_+_2025922 0.920 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr19_+_59941785 0.917 NM_015868
KIR2DS2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr22_+_21870293 0.914


chr22_+_18085990 0.913 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr1_+_32447281 0.909 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr21_+_36993302 0.904


chr4_-_8124611 0.902 ABLIM2
actin binding LIM protein family, member 2
chr19_+_59833719 0.901 NM_001081638
NM_001081639
NM_001081637
LILRB1


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


chr12_+_56406296 0.894 LOC100130776
hypothetical LOC100130776
chr1_+_154855709 0.894 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr1_-_39180036 0.894 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr11_+_63876924 0.891 CCDC88B
coiled-coil domain containing 88B
chr6_-_39305203 0.890 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr8_+_22078589 0.889 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr10_-_13316333 0.887 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr14_+_22581215 0.887 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.77 7.40e-07 GO:0044421 extracellular region part
1.44 2.07e-05 GO:0044459 plasma membrane part
1.46 2.78e-05 GO:0005576 extracellular region
1.71 3.88e-04 GO:0005615 extracellular space
1.51 1.43e-03 GO:0031226 intrinsic to plasma membrane
2.11 1.60e-03 GO:0005578 proteinaceous extracellular matrix
1.49 4.56e-03 GO:0005887 integral to plasma membrane
1.87 1.92e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.55 4.38e-02 GO:0009008 DNA-methyltransferase activity